Akkaraman ve Romanov Kuzularının Alveolar Makrofajlarında Lipopolisakkarit ve Lipoteikoik Asite Yanıtta İmmün İlişkili Genlerin Ekspresyon Profilinin Araştırılması

The alveolar macrophages (AMs) are frontier of defense against foreign materials that initiate immune response in lungs. Knowledge the expression dynamics major immune-related genes to lipopolysaccharide (LPS) and lipoteichoic acid (LTA) challenge can help understand disease mechanism involved several respiratory diseases. aim this study was investigate mRNA selected sheep vivo. Results revealed Romanov lambs exhibited higher TLR2, TLR4, NF-ĸβ, TNFα, IL-1β, IL-6, IL-8, IL-10 as compared Akkaraman along with control all treatments. Moreover, combine treatment LPS LTA separate treatments both breeds. results showed significantly increased AMs whereas a synergistic effect observed LPS+LTS treatment. Also, breed comparison native more resistant exotic Romanov.